Cause Of Polycystic Ovary Syndrome Discovered At Last
If you’re at the reproductive age, you don’t want to suffer from polycystic ovary syndrome (PCOS), especially if you're looking forward to having children someday.
Polycystic Ovary Syndrome
Women with PCOS have prolonged or infrequent menstrual periods. This is because there's an excessive amount of the androgen male hormone. The ovaries don’t regularly release eggs due to their developing many small collections of fluid.
Irregular menstrual cycles, ovarian cysts, high levels of the male hormone testosterone, and difficulties regulating sugar are common to polycystic ovary syndrome. Until recently, the causes of this syndrome have remained a mystery.
As many as one in ten women globally are affected by polycystic ovary syndrome. Three-quarters of the women with this syndrome seem to be unable to become pregnant.
Accounts of women with infertility problems as well as infertility treatment were considerably higher in women reporting PCOS.
Although infertility treatments are available for women affected by PCOS to get pregnant, the success rate across five menstrual cycles is less than 30 percent.
Robert Norman at the University of Adelaide in Australia remarked that PCOS, “Is by far the most common hormonal condition affecting women of reproductive age, but it hasn’t received a lot of attention.”
Changes in the Womb
Paolo Giacobini and his colleagues at the French National Institute of Health and Medical Research learned that many women who had polycystic ovary syndrome had 30 percent higher levels of anti-Müllerian hormones than normal.
Knowing that the syndrome runs in families, they naturally deduced that the hormonal imbalance during pregnancy may induce the same in their daughters.
Consequently, they decided to test the idea of the syndrome being an inherited trait. They conducted an experiment on pregnant mice in which they injected excessive amounts of the anti-Müllerian hormone into them.
The female young showed many of the polycystic ovary syndrome peculiarities as they grew up. These peculiarities were infrequent ovulation, later puberty, delays in becoming pregnant, and fewer offspring.
The hormone excess seemed to overstimulate some brain cells and elevate their testosterone levels.
A Cure Discovered in the Mice
By using an IVF drug, cetrorelix, regularly, the team reversed the effect in the mice. Women’s hormones were ordinarily controlled by this IVF drug. After the mice were treated with this drug, they no longer showed polycystic ovary syndrome symptoms.
The next step for the team is to conduct a clinical trial on woman showing signs of the condition. For this clinical trial, the team will administer the cetrorelix to women showing symptoms of the polycystic ovary syndrome.
They plan to begin this trial before this year’s end. Giacobini claims this trial could be an attractive way to both restore ovulation and raise the rate of pregnancy in these women.
Norman suggests, “It’s a radical new way of thinking about polycystic ovary syndrome and opens up a whole range of opportunities for further investigation”.
According to Norman, women with the syndrome tend to become pregnant easily in their late 30s and early 40s. In men, the levels of the Anti-Müllerian hormone decline as a man gets older.
For men, this signals a reduction in fertility. However, in a woman, the reduction of the hormone may bring them to the normal range for fertility, but this needs further testing.
What do you think? Are they on the right track? Do you believe a woman with PCOS can pass the syndrome on to her daughters?
Anyone with PCOS needs to read this.
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