Amy Schumer Opens Up About Botched Colonoscopy and Its Unexpected Side Effect

May 20, 2026 by apost team

Amy Schumer has always been one of the most candid voices in comedy — on stage, on screen, and in her own life. She was the first mainstream comedian to speak openly about Cushing syndrome, caused by steroid injections she had been receiving, which led to a dramatic change in her appearance that the internet had been scrutinizing for years. She documented her experience with weight loss drugs, including the side effects that left her bedridden. She has spoken about endometriosis, perimenopause, and the realities of motherhood as a single parent since her split from husband Chris Fischer.

Schumer, born June 1, 1981, and Fischer confirmed their separation in December 2025 after nearly eight years of marriage. In January 2026, she filed for an uncontested divorce. The two share a son, Gene Attell Fischer, born May 5, 2019. Since the split, Schumer has been open about navigating a new chapter — one she has described with characteristic directness as better than she expected.

"I feel happier than I've ever been before," she told the audience at a Dear Media event for the podcast "Not Skinny But Not Fat" at Webster Hall in New York City on May 17, 2026. Host Amanda Hirsch had asked whether her recent weight loss had anything to do with "being really hot." Schumer appreciated the compliment — but she had something else to add.

She paused. She looked at the audience. And then she said the thing that nobody in that room — or online the next morning — was quite expecting. It was vintage Schumer: a medical disclosure, delivered as a punchline, with a straight face.

"I actually had kind of a botched colonoscopy, so I'm not feeling very sexual,"

Schumer told the audience. The line landed immediately — and then she leaned into it.

"See, that's another thing you're not going to have to worry about for 15 years, OK?"

she added, nodding to the audience's presumably younger demographic.

She did not share additional details about the procedure — what went wrong, when it happened, or what the medical consequences were. The comment was delivered with the kind of comedic timing that has defined her career, but the underlying message was real: something had gone wrong during a routine screening, and she was still feeling the effects.

The remark landed in the context of a broader health journey that Schumer has shared more openly than almost any public figure in recent years. She previously documented severe side effects from Wegovy and later a better experience with Mounjaro, as well as the discovery that she was in perimenopause. In September 2021, she underwent surgery to remove her uterus and appendix due to endometriosis. Each disclosure has followed the same pattern: candid, funny, and delivered without apology.

The colonoscopy comment was no different — except for the fact that it arrived on the same night she was also telling audiences that she feels happier than she ever has. The procedure may have been botched. Her personal life may have recently been upended. But Schumer, by her own account, is doing better than ever. She just wanted to be honest about all of it — the good, the complicated, and the parts that are still healing.

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